Response Inhibition Function of Obsessive-Compulsive Patients with Obsessive-Compulsive Personality Disorder

Objective: To explore the effect of comorbid obsessive-compulsive personality disorder (OCPD) on response inhibition functions in patients with obsessive-compulsive disorder (OCD). Methods: Forty-five obsessive-compulsive patients with obsessivecompulsive personality disorder (OCD + OCPD), 42 obsessivecompulsive patients without obsessive-compulsive personality disorder (OCD OCPD) and 54 healthy volunteers were selected for the stopsignal task. Results: Obsessive-compulsive patients with obsessive-compulsive personality disorder had a higher score of depression and anxiety and more severe obsessive-compulsive symptoms than that of obsessivecompulsive patients without obsessive-compulsive personality disorder. The two groups of obsessive-compulsive patients of had a greater stop-signal reaction time (SSRT) during the inhibition process than the healthy volunteers of the control group (OCD + OCPD: 221.45 ± 31.78; OCD OCPD: 218.36 ± 31.78; Controls: 199.29 ± 22.80; p < 0.05). However, no significant difference was found between the two groups of obsessive-compulsive patients. Conclusion: The findings show that the comorbid obsessivecompulsive personality disorder has no effect on response inhibition function of obsessive-compulsive patients.